Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0056gp241 | Thyroid Cancer - Translational | ECE2018

Detection of lncRNAs in thyroid nodule as new tool for tumor diagnosis: analysis by Droplet Digital PCR in Fine Needle Aspiration biopsy

Nanni Simona , Locantore Pietro , Bacci Lorenza , Aurora Aiello , Fadda Guido , Traini Emanuela , Bellantone Rocco , Grassi Claudio , Farsetti Antonella , Pontecorvi Alfredo

Background: Differentiated Thyroid Carcinomas (DTC) represent more than 90% of thyroid tumors with good prognosis and long survival. Currently, patients with intermediate/high risk nodule as assessed by cytological staging may undergo surgery. According to ATA 2017 guidelines, all patients presenting thyroid nodules with suspicious ultrasound features (hypoechoic pattern, irregular margins, microcalcifications, etc.) and cytopathology TIR3B, TIR4 or TIR5 according to 2014-SIAP...
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ea0093oc51 | Oral communication 8: Interdisciplinary Endocrinology and Environment, Society and Governance | EYES2023

Identifying and characterizing novel HSP90 inhibitors with senolytic activity in a hormone-induced breast cancer-senescence model

Cis Luca , Atlante Sandra , De Martino Sara , Cencioni Chiara , Aiello Aurora , Pirolli Davide , Malavolta Marco , Nanni Simona , De Rosa Maria Cristina , Gaetano Carlo , Farsetti Antonella

Background: Cell senescence is characterized by halted cell proliferation and the acquisition of a pro-inflammatory profile. Cancer cells can enter into senescent state following treatments that inflict DNA damage. Intriguingly, these cells can evade the senescent state, gaining enhanced proliferative capabilities and resistance to further treatment, thereby prompting tumor recurrence. Senolytics offer the potential to eradicate selectively senescent cells, preventing tumor re...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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